Therapeutic applications of tincture at 10 % from Calendula officinalis in Recurrent Aphthous Stomatitis
Abstract
A study about the use of medications (indication-prescription) was realized, prospective in patients with buccal illness, using a tincture at 10 % from Calendula officinalis as therapeutic option, in four different clinics in Havana City, Cuba. 110 patients were chosen randomly, and were collected data from 60 physicians. Results were measured as treatmentresponse, time of improvement and used dosis with time of improvement. The sample answered to the treatment at 90 %, and from them, 73.7 % in a period between 3-6 days, and 26.3 % in a period of 7-10 days. Calendula officinalis tincture at 10 % was effective in treatment of buccal infections corroborating its antibacterial and anti-inflammatories properties due to the presence of volatile oils, and flavonoids, among others.
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Introduction
Oral cavity is the entry gate of foods, vitamins, liquids, medications and other that has introducing into the organism. Oral infections are one of the most frequent causes found out in medical practice. Aphtha or buccal ulcers are injuries that appear in oral mucous, when its localization is located to the mouth and not like a consequence of some systemic illness, receiving the name of recurrent aphthous stomatitis (RAS). Probably, an immunological dysfunction jointed to diverse unchain factors facilitate aphtha appearance. That local immunological dysfunction will be related with an increase of lymphocytes T populations (CD4 and CD8) and an increase of α-TNF (Herrera et al., 2015; Cui et al., 2016).
One of most representative periodontal illness by its frequency and symptomatology is recurrent aphthous stomatitis (RAS), which constitute one of stemmatological infections that require immediate attention due to the provoke inconveniences at patients. Affect both sex, but principally female sex in any age, even though is more frequent in teenager associated to risk factors like stress, gastrointestinal disorders, microorganisms (virus, bacteria, fungus), smoke habit, traumatism, psychosomatic and immunity alterations, endocrine factors, nutritional deficiency, allergy, and a hereditary component (González & Montero, 2013; Pérez & Rodríguez, 2006; Solís et al., 2017).
Recurrent aphthous stomatitis (RAS) is one of the most common painful oral mucosal conditions seen among patients. These present as recurrent, multiple, small, round, or ovoid ulcers, with circumscribed margins, having yellow or gray floors and are surrounded by erythematous haloes, present first in childhood or adolescence (Jurge et al., 2006). RAS is characterized by recurrent bouts of solitary or multiple shallow painful ulcers, at intervals of few months to few days in patients who are otherwise well (Scully & Porter, 2008).
Conclusion
Information degree of interviewed stemmatologist about the use of calendula’s tincture at 10 % was qualified as middle adequate knowledge. Female sex predominated in patients with RAS as well as ages between 30-59 years’ old. Predominant RAS was of minor type (54.5 %), followed by herpetiform (22.7 %). Treatment of lesions in time with tincture of calendula at 10 % result between 3-6 days, fundamentally with a posology of 5 drops/100 mL of water, with the 90 % of patients cured before the 10 days of initialized the therapy. Effectiveness of therapy with tincture at 10 % of calendula was evaluated in a 90 % of whole cases. Authors recommend designing effectiveness or efficacy tests in a clinic and aleatory assay, to demonstrate the definitive efficacy of tincture of C. officinalis in this one and other stemmatological affections.